Mini Kidney on a 3D-Printed Chip

Mini Kidney on a 3D-Printed Chip Mini Kidney on a 3D-Printed Chip Mini Kidney on a 3D-Printed ChipUsing a novel biomechanical approach, a team of researchers at Harvard Universitys School of Engineering and Applied Sciences and Harvard Medical School have grown miniature kidney organoids on a chip. Compared with lab-grown kidney tissues, the organoids displayed a system of blood vessels that enables the tiny organoids to perform many of the functions of working kidneys.In the body, kidneysperform multiple functions such as cleaning blood, filtering nutrients, and making urine. Each human kidney contains about a million functional units called nephrons, whichregulate the concentration of water and soluble substances such as salts, reabsorb nutrients and excrete the rest.Listen to the latest episode of ASME TechCast Breakthrough Could Bring New Cancer TreatmentEach nephronconsists of a glomerulus and an attached tubule. Together, they filter and clean the bloodstream. Sp ecially designed microfluidic chips use fluid flow to provide the mechanical clues kidney tissue needs to growth more mature vascular networks. leistungspunkt Wyss Institute at Harvard UniversityThe glomerulus acts as the gatekeeper, channeling blood components, such as red and white cells, back into the bloodstream while directing everything else into the tubule. Inside the tubule, specialized cells sift through the flow, pulling out amino acids, glucose, and other nutrients to return to the bloodstream while channeling toxins, infectious agents, and other harmful substances into the urine.These functions rely on kidneys robust network of blood vessels, through which the exchange of nutrients and waste products takes place, explained Kimberly Homan, research associate at the Harvards School of Engineering and Materials Sciences.In recent years, several laboratories have managed to grow kidney cells in culture dishes. The resulting tissues, however, lacked the functional vasculature needed to clean and filter blood products. When researchers tried to stimulate blood vessel growth with biochemical cues and growth factors, they failed.The study advances kidney research by helping us better understand the effect of aufgetaut flow during organ development. Benjamin Freedman, University of WashingtonInstead of this traditional approach, the Harvard group worked with fluidic shear stressesthe force generated by fluid flowing over the organoidsthat mimicked the natural conditions in which kidney tissues develop in the human body.The researchers first grew the organoids from stem cells and then placed them in a 3D-printed chip containing an extracellular matrix, a supporting scaffold with mechanical properties similar to natural cellular matrix.Then the team flowed a nutrient-rich fluid over the developing organoids for 10 days. The force generated by the flowing liquid provided the necessary physiological cue the organoids needed to start growing vasculature.Read mor e on Biomechanics How to Make a More Precise Hypodermic NeedleThe resulting organoids displayed more mature kidney blood vessels structure than those grown in static culture.In fact, the team observed a tenfold increase in vessel length and junction density (the amount of blood vessel branching per unit area). Kimberly Homan 3D prints stem cell-derived tissues to create kidney tissues that mimic native kidneys. Such organoids could be used to test medications and model diseases. Image Wyss Institute at Harvard UniversityThe structure of the perfused organoids also differed from those grown statically. In real kidneys, cells inside tubules develop specific organelles called cilia and microvilli, tiny hair-like structures that pluck nutrients from the body fluids and send them back into the bloodstream. These cells also orient themselves in a polarized waythey line up in a specific fashion to redirect nutrients into the blood. The static tissue cultures never achieve th is level of maturity, but organoids grown under fluid flow.We are getting kidney tissue that is maturing to a level that we have not encountered before with organoids grown in static culture, Homan said. The cells have a better expression of essential transporters needed for biological kidney function.The team sees several possible applications for this work.Our ultimate goal is to grow kidney transplants, said co-author Ryuji Morizane, assistant hochschulprofessor at Brigham and Womens Hospital and Harvard Medical School.Growing artificial kidneys may take years. A more likely near-term application could involve using lab-grown kidney tissue in drug testing, which would enable researchers to use human kidney models while reducing the use of animal test subjects.Meanwhile, the fluidic flow technique promises to advance kidney research. As Morizane noted, We can observe urinary production in the culture plate and see how native kidney works.Read more on Interdisciplinary Approach to Bioengineering 6 Ways Engineers Heal a Broken HeartGrowing functional tissue in the lab is a major challenge that has not yet been met, Benjamin Freedman said. He is an assistant professor of medicine and nephrology at the Institute for Stem Cell and Regenerative Medicine at the University of Washington and was not involved in the study.The study advances kidney research by helping us better understand the effect of liquid flow during organ development, he said. In particular, it is interesting that fluid flow stimulates the growth of endothelial cellsblood vessel cellsinside the kidney structures. The blood vessels are an important component of kidney tissue, and right now we dont have ways of accurately re-creating that architecture.Freedman also pointed out that the Harvard team derived kidney cells from stem cells, which is less invasive than harvesting kidney cells from patients. Doctors can use patients own cells to grow kidney structures to better diagnose their nephrology pr oblems.In theory, we may be able to use this type of approach to diagnose aspects of a patients kidney health using these types of devices as a surrogate for their kidneys, he said.Freedman also thinks that the studys approach advances the field of medicine even beyond nephrology and may be applicable for many types of organs.By merging blood vessel structures with organoid structures, we may in the future be able to generate functional tissue grafts outside of the body, he said.Lina Zeldovich is a freelance writer based in Woodside, N.Y.

What Are the Differences Between Attending a Regional Law Sc

What Are the Differences Between Attending a Regional Law ScWhat Are the Differences Between Attending a Regional Law ScThe biggest influencing factors when students consider attending law school are the institutions prestige and its location, according to a Vault law school survey. The fact that these two factors weigh so significantly into an applicants decision-making process shows just how difficult it can be when weighing the different and very personal pros and cons of going to a regional law school against those of attending a national law school. What are the benefits, challenges of each? The myths? How does the current legal market affect your decision?Listen up as Vaults Brian Dalton, and four law school deans, explain in this podcast the basics of what you need to know about the differences between regional and national law schools. Even if your question is, Whats a regional and national law school? This is just a three-minute preview. To hear the rest go here.Law School P odcasterRelated Top 5 Law Schools by Employment The Best Program for Where You Live

Don#8217;t Provide a Job Provide an Experience

Don8217t Provide a Job Provide an Experience Don8217t Provide a Job Provide an Experience Weve all had that job that left us exhausted and disappointed at the end of every day. Companies that create this kind of environment inevitably deal with high turnover and low productivity. Successful businesses need to create work environments in which employees truly thrive. Common sense tells us that a worker who feels appreciated and excited about their job will always work harder than one who hates coming to work. Give those disgruntled workers the chance to move on to something more engaging, and theyll jump at it.Instead of being a temporary stop for a long series of disgruntled employees, companies should be working to engage employees in positive ways to drive retention. However, many talent professionals find it challengingto create engaging employee experiences for onboarding, perfassonance, and learning, and 51 percent worry about motivating employees around company goals, accor ding to the State of Talent 2017 Report from talent management solutions provider SilkRoad. Creating Engaging Employee ExperiencesThe first step to increasing employee engagement is simple Talk to them.Clear, transparent, ongoing communication from the top down is the first and arguably most important step in engaging employees at every point in their career, says ambra Hyatt, SPHR, SHRM-SCP, vice president, product marketing for SilkRoad. Through an agile performance approach, which relies upon frequent manager and employee check-ins, real-time feedback, and two-way communication, organizations can ensure employee expectations and goals align with business objectives. Similarly, companies should look for opportunities to gather feedback directly from employees. Open forums and focus groups for new projects are great ways to solicit input from employees, strengthening two-way communication and boosting engagement.However, this doesnt mean executives can solve all their engagement pr oblems by chatting up employees. A business that provides lasting and successful employee engagement must establish it as a core principle of the corporate culture.Before organizations can excite employees with their cultures, they need to have strong value propositions and echo them throughout all of their efforts, Hyatt says. This creates a solid and unmissable foundation on which to build excitement.Once these foundations are in place, employers should excite employees by recognizing them, Hyatt says. This includes honoring their achievements both publicly and in one-on-one meetings.Next, look for opportunities to invest in building the team, including social events and off-site excursions where team members can get to know one another outside of the office, Hyatt suggests. And of course, utilize frequent communication to keep employees abreast of new customer feedback, project completion dates, departmental reporting, etc. All of these steps combine to create a culture of engage ment. Employees who understand the impact their efforts make on organizational goals remain engaged and exited.Find Out What Employees Need Before Its Too LateMaintaining frequent contact throughout each employees tenure helps workers feel valued by the company.Traditional talent management is centered on individual processes employees must complete, including applying for a job, signing an offer, filling out new hire paperwork, and even receiving paychecks, says Hyatt. While automation of these processes may benefit HR, it does little to improve the day-to-day employee experience. Every interaction an employee has with an organization is a single touchpoint in one continuous employee experience in which they form ongoing impressions of the organization.By making the effort to engage employees on a personal level, businesses show each individual worker that they have value and that their voice is heard.By shifting the focus to the employee experience, organizations can create meani ngful moments throughout the employees entire tenure, Hyatt says. One great way to do this is by collecting employee feedback at each stage of their journey and acting on it wherever possible.Employees leave organizations for many reasons. Waiting until the exit interview to find out why an employee jumped ship can help you address the problem for future employees, but its too late to do anything about the employee who is leaving.If that feedback had been collected at an earlier point, the organization could have taken steps to fix potential problems and keep a valuable employee from seeking opportunities elsewhere, Hyatt says. By understanding that the employee journey is a continuum of experiences, organizations can ensure they make a positive impact through an agile performance approach with consistent two-way communication, real-time feedback, and alignment with company goals. This engages and excites employees with positive employee experiences.

How to Hire a Recruiter

How to Hire a RecruiterHow to Hire a RecruiterStaffing agencies are experts at making matches, whether you want to find a professional who will take your team to the next level, or youre looking for a rewarding career opportunity for yourself. But how do you go about choosing the right service for you or your company? You need to know how to hire a recruiter.An expert recruiter can help identify your needs, launch a search, evaluate candidates or employers, and reduce the time and stress associated with finding new staff or a new job.Technically, when youre seeking a job and working with a staffing agency, you wont be hiring a recruiter. Firms typically charge a fee to employers to find them top candidates, but most dont charge job seekers for their services.Lets start with employers who want to streamline the hiring process by engaging with a recruiting firm.How to hire a recruiter - for employersConsider the following factors when choosing a reputable staffing agencySpecialization - Staffing agencies have access to a pool of candidates with in-demand skills and relevant experience. Some of them may even be passive job seekers who would consider changing roles to work for you. Look for recruiters at specialized agencies who can offer deep expertise in your industry and a unique perspective.Client lists - Read customer testimonials and ask to see a list of companies the firm has worked with. The ideal recruitment service has experience working with your size and type of business.Scope - How broad are the networks of the recruiting firm? Do the recruiters have access to candidates you dont? Have professionals already been vetted? The best recruiters have cultivated a rich pipeline of job seekers through their networking efforts and by placing professionals in jobs and staying connected with them.Hiring process - How long is the search expected to take? What evaluations will the recruiters perform before you meet a potential hire? How many individuals will y ou interview? The best recruitment agencies will save you save you the time of wading through a multitude of resumes from unqualified applicants.Dedication - Is the recruiter committed to making an ideal match for you? The best ones will help you find someone who fits your corporate culture and is suited to your work environment. That will help eliminate staff turnover and the cost of a bad hire.How to hire a recruiter - for job seekersStaffing services can provide you a head start on finding available jobs, connect you with valuable industry contacts and alert you to promising opportunities as they become available. Establishing an ongoing relationship with a recruiter can also benefit your career in the long run, even if you arent actively looking for a new job.Consider the following factors when starting the recruitment process for your job searchReputation Be sure to research the firms history, accolades and alliance partners to get an idea of its standing in the industry. Ask for references.Available jobs Browse the job listings on the recruiting firms website. Look at job titles, locations and the number of openings available in your field.Staff interaction Meet with the staffing agency, paying attention to the level of professionalism and customer service it offers. Take note of how well the firms representatives follow up with you after your visits. Remember, youre entrusting your professional future to this company, so you want to feel comfortable working with it.Policies Make sure you understand the ins and outs of working with a recruiter. Will you be working with one person or a team? How often will you receive updates? How quickly are new positions typically found? Be wary of any staffing agency that charges job seekers for their services.Additional services Some staffing agencies provide additional career resources, such as resume-writing help, recommendations about continuing education and interview coaching.Make sure you understand how involv ed you are expected to be when working with a recruiter. The best firms will handle the heavy lifting for you and will remain in touch to meet your unique needs.If youre ready to approach a staffing agency, learn how can help you find the right job

The Secret Truth About Business Analyst Resume Summary Revealed

The Secret Truth About Business Analyst Resume Summary Revealed The ideal Business Analyst Resume Skills for Hard Skills rely on the geschftsleben or company which you work for. Whether you wish to receive your very first interview for a Business Analyst. Or even when you just need some practical suggestions about how to compose your resume for a new Business Analyst role. The part of a Business Analyst will be different from industry to industry. A career for a geschftsleben analyst can be very rewarding. The typical monthly salary of a company analyst is over $5,000. He needs to be an excellent communicator. A certified small business analyst resume is a resume which certifies the experience and qualifications of a company analyst whos interested to work for a specific organization. Whether youre a recent graduate, a mid-level manager, an executive with several years of experience, or simply someone seeking to change career paths, theres a resume format that could really make you appear great to a hiring manager. However good youre in your work, if your resume isnt up to the mark, its likely that the recruiters wouldnt even know you exist. A great coaching skill is going to be necessary for the analyst to be in a position to effectively teach others. Talk about the sorts of teams you worked on, and the way you succeeded. When youre searching for analyst jobs, its crucial that your resume be as strong as possible. Its therefore important that analysts ought to be in a position to work independently. If you want to turn into a business analyst, youre in high demand. Not having experience for a business analyst really isnt the close of the world. If youre on the lookout for a business analyst role in an organization, you need to know there are certain skill sets you should bring out in your resume. There are lots of resume examples on the net, so all you must do is search for them. A good resume will also catch the eye of the employers and re cruiters who want to employ a business analyst whos experienced and dependable. Top Business Analyst Resume Summary Choices Building on your analytical abilities, you should also be in a position to examine the data and use from the box thinking to address solutions for your clientele. You have to understand new outcomes that could be accomplished on the exact platforms, whilst having a great comprehension of the benefits the latest technology offers. By way of example, folks say that Business Analysts must have the ability to compose excellent requirements or create decent use cases. Business analysts work to create a shared comprehension of difficulties, outline the parameters of the undertaking, and determine prospective solutions. Business Analyst Resume Summary for Dummies Suppose that when the company would like to sell the earlier mentioned product on a site, the user must press a massive blue button to visit the next page and keep entering information. You should EAS ILY have the ability to continue to keep your resume to just two pages from now on. You need to be able to listen and absorb information. This information can help you in your search. Ensuring that theres enough white-space on your resume and it has a balanced look will boost its readability. You may observe that in the work description. Bear in mind, your resume is only going to receive a few seconds attention, at best Or, if youre strapped for time, try out our easy-to-use resume builder that could bring in a custom resume in almost no time whatsoever. Defect management is the procedure of managing system defects. Business analysis can encompass a number of responsibilities that are particular to the field theyre in. Business Analysts are tasked to generate the organization run better by finding solutions to current difficulties, introduce efficient means of managing responsibilities and searching for comparative benefits versus competition in the business. Professiona l small business analysts play a crucial part in a providers productivity, efficiency, and profitability. When you have Customer Support as your job title, you are more inclined to find customer support positions. You may also see resumes can easily be found online. A Business Analyst Resume should showcase an assortment of qualities that prove ones capacity to effectively oversee the einzelschritt of an organization. Being a thriving Business Analyst means youve got to get a number of distinct abilities and be adaptable to a changing atmosphere. A team player who is famous for her excellent verbal and written communication abilities. There are lots of skills that you ought to include on your resume, and they vary wildly depending on the precise type of analysis job youre pursuing. Possessing the technical skills of a BA or understanding how to compose perfect requirements specifications is inadequate. Choosing Good Business Analyst Resume Summary If you find out more abo ut the position well enough, there is no good reason for you not to be in a position to compose a very good summary. In that instance, you can fix your summary section accordingly. If you do a resume example search, you will likewise find cover letter examples also. You just need to pick the one which you must use and then use your resume example in order to produce the very best letter for your resume.

Top Writing an Objective Summary for Resume Tips!

Top Writing an Objective Summary for Resume Tips A summary statement is a brief expert introduction which you can increase the peak of your resume. Your objective statement is the very first thing theyll see and read, since its the very first thing on the webpage. For entry level applicants, your objective summary ought to be practical and right to the point. While writing the resume, you may use the overview of your qualifications at the start. Finding Writing an Objective Summary for Resume Online It is very important to keep in mind that the greatest objective summaries are especially tailored to coincide with the punkt youre applying for. My aim is to find the job. As a result, while your resume objective should incorporate information on the career which you want, you also wish to spell out why you are the perfect candidate for the job. The absolute most efficient objective is one which is tailored to the job youre applying for. What You Can Do About Writing an Objecti ve Summary for Resume Beginning in the Next Eight Minutes In summary, your objective summary should specify your target and the value it is possible to increase the corporation. You might not know where to start in regards to writing a resume objective. An objective must be personally-tailored to the employer. Ultimately, stating it is optional, but it can help convince employers that you know what you want and are familiar with the industry. What You Dont Know About Writing an Objective Summary for Resume A summary statement should include a few specific, work-related abilities, and some relevant soft skills. Writing a resume summary statement might be new to you if its been a while as you have updated your resume. The Death of Writing an Objective Summary for Resume 1 A resume summary is a brief, snappy introduction paragraph that offers a summary of your very best work. You might also see chapter summary. You may want to look at a qualifications summary which we outli ned in last weeks postbut if you simply need to have a summaryhere are a couple examples to help you begin. Because resumes have limited space, your career objective has to be concise. An excellent career summary is basically a glimpse of your skill set and the value its possible to bring to your prospective employer. Finally, it focuses on your ability to offer value to the company. A well written objective summary must include your particular skill set, your principal goal and the way youre able to be of help to the corporation. In reservierung to understand what to have in your career summary, you will need to understand what it is and what it isnt. As stated above, a career summary isnt a career objective. Essentially, your career summary has to be forward-looking. Last, you should remember to proofread your career summary like the remainder of your resume. Writing an Objective Summary for Resume at a Glance Possessing a brief statement or overview at the start of you r resume is a good way to demonstrate your abilities and experience and show the hiring manager the value which you will bring to the position. You would like to sell your skills in a fashion that will garner an interview. If you follow the advice above you will have an interesting, compelling resume summary that is likely to make the reader want to find out more about you even regardless of your lack of work experience A career summary on the opposite hand, is a concise breakdown of your prior work experiences. The Basic Principles of Writing an Objective Summary for Resume That You Can Learn From Beginning Today LinkedIn summaries are very different. Your career summary also has to be specific and relevant.